Many comparisons create many opportunities to flag

If a system monitors many locations, conditions, and time windows, some unusual-looking results can occur by chance. A threshold that seems rare for one comparison may generate frequent alerts across the whole system.

The alert process needs to account for that monitoring context.

An alert is not an outbreak declaration

The next step may be checking data quality, reviewing cases, or seeking corroborating evidence. The workflow should say who does that and how quickly.

Design questionWhy it matters
What change matters?Defines the detection target
What false-alert burden is manageable?Connects statistics to staffing
What follow-up is available?Makes the signal actionable
What is missed?Keeps sensitivity limits visible

Evaluate in realistic conditions

Historical testing can help assess detection timing and false signals, but the data should resemble the deployed reporting process, including delays and revisions. Testing only on cleaned final data can overstate real-time performance.

The best threshold is not simply the one producing the most alarms or the fewest. It is part of a system that can identify meaningful changes and respond appropriately without exhausting its capacity on signals it cannot interpret.